Detwiller is known for his etchings and lithographs of industrial New York. He captured the construction of the Hell Gate Bridge and the busy docks of the East River. His work often focuses on the geometry of steel and stone. He used strong lines to define the scale of modern engineering. His maritime paintings from the First World War show a similar interest in the anatomy of ships. He often worked on site to ensure his drawings reflected the actual mechanics of the structures.

Collectors today value Detwiller for his documented views of a changing urban environment. His prints provide a clear record of early twentieth-century infrastructure. They fit well in modern interiors because of their graphic clarity and neutral colours. His ability to find balance in heavy industrial subjects makes his work a popular choice for home offices and living spaces. These works offer a sense of historical stability and craftsmanship to a room.