Moretto was noted for his depiction of materials. He devoted significant effort to the details of cloth of gold or heavy velvets. His palette is characterised by cool, silvery tones. He painted figures that resembled the citizens of his own town. This focus on light and substance provided a technical foundation for later artists like Caravaggio. He balanced formal composition with a direct observation of nature.

Collectors appreciate the calm atmosphere of these works. The art avoids the frantic energy of the later Mannerist period. It offers a sense of stillness and physical weight. The muted colours and realistic textures suit contemporary interior design. His ability to capture the physical presence of his subjects provides a clear window into sixteenth-century Italy.