His approach combined the structural logic of Cubism with a personal interest in nature. In works like Rocky Mountains and Blue Flowers, he used flat planes of colour and sharp, dark outlines to define space. He avoided traditional perspective. Instead, he built compositions through the interaction of shapes and the weight of his brushstrokes. His style is defined by a sense of controlled energy where every mark has a purpose.

Modern collectors value Vytlacil for his ability to balance abstraction with recognisable subjects. His prints provide a sophisticated aesthetic that complements contemporary interior design. The work is direct and lacks unnecessary ornamentation. Because he often painted on both sides of a surface, as seen in Untitled (recto and verso), his process shows a constant search for form. His art remains a popular choice for those who appreciate the origins of American modernism.