Serebryakova was a member of the World of Art movement. She worked across various media including oils and gouache. During the 1920s, she began to use pastels frequently. Her work often features domestic scenes such as her children at dinner or the quiet movements of ballet dancers. She combined elements of Realism and Impressionism with a focus on direct observation. This approach resulted in portraits that possess a distinct sense of tranquillity. Her later travels to North Africa introduced new subjects to her catalogue of work.

Modern collectors value Serebryakova for her ability to capture a sense of calm within a home. Her paintings of family life and the natural world avoid the heavy drama of her contemporaries. The informal quality of her pastel sketches makes them suitable for contemporary interiors. Her art offers a window into a private world of grace and balance. These works remain popular for their clarity and their honest depiction of the human form.