The artist is best known for his profile portraits, such as his depiction of Bianca Maria Sforza. This format reflects his early experience with coinage. His style combines the rigid formality of traditional Italian portraiture with the softer, more naturalistic techniques he learned from Leonardo. This blend is evident in his treatment of light and shadow in works like Portrait of a Young Man. Many of his paintings were so closely aligned with the style of his contemporary that scholars spent centuries debating which man held the brush.

Modern collectors value de Predis for his ability to capture the quiet dignity of his subjects. His portraits offer a direct connection to the Renaissance court through their clear lines and focused compositions. The use of X-radiograph technology on his works has revealed the layers of his process and his frequent revisions. These prints provide a sense of historical weight without visual clutter. They suit contemporary interiors that favour clean forms and historical character.