Mocetto adapted the designs of his contemporaries into his own style. His engravings, such as "The Calumny of Apelles", show a preference for firm outlines and structured architectural settings. He used a technique of fine, parallel hatching to create volume rather than the soft blending seen in many Venetian paintings. This linear approach gives his work a clarity that distinguishes it from the atmospheric works of the period. His compositions include classical motifs and mythological figures, such as tritons or nymphs, which he integrated with traditional religious subjects.

The prints of Girolamo Mocetto offer a window into the Renaissance in Venice. His work provides a sense of order through its careful geometry and clear perspectives. Collectors value his prints for their historical accuracy and their depiction of early sixteenth-century Venetian aesthetics. The monochrome nature of his engravings makes them suitable for contemporary interiors where a balance of classical form and neutral tones is desired. These pieces provide a direct link to the workshop traditions of the Republic of Venice.