Vermeyen was a central figure in the Habsburg court, serving as the official painter for Margaret of Austria and Mary, Queen of Hungary. His style belongs to the Northern Renaissance, characterised by sharp precision and a focus on individual character. In his Portrait of Henry II of France and the Portret van Erard de la Marck, he used clear lines to define the status of his sitters. Unlike many contemporaries who softened features, Vermeyen often recorded the physical realities of his subjects. His religious works, such as De Heilige familie and The Lamentation, maintain this same clarity while incorporating the elongated forms of early Mannerism.

Modern collectors value Vermeyen for his directness and historical accuracy. His portraits, including the Portrait of a Man with a Rosary, function as windows into the power structures of the sixteenth-century Netherlands and Spain. The work is devoid of unnecessary ornamentation, making it suitable for contemporary interiors that favour clean lines and historical weight. These prints offer a connection to the intellectual and political world of the Habsburg Empire through the eyes of an artist who witnessed history in person.