His work follows the Mannerist aesthetic of the 16th century. He preferred elongated limbs and complex poses. His etchings often depict mythological scenes or architectural fantasies. Unlike the clean lines of Italian engraving, Mignon used dense hatching to create movement. This technique gave his prints a silvery quality that differed from the rigid standards of his time.

Modern collectors value Mignon for his bold graphic quality and historical connection to the French Renaissance. His etchings offer a window into the decorative world of King Francis I. The contrast between his classical subjects and his expressive line work makes his art a strong choice for contemporary interiors. These etchings provide a sense of history without feeling dated.