A 1508 oil painting by Lorenzo Lotto depicting the Virgin and Child with a bishop saint and St. Onuphrius, captured in the High Renaissance style.

Painted in 1508, this work by Lorenzo Lotto displays the artist's early mastery of Venetian colour and psychological depth. The composition features the Virgin Mary holding the Christ Child, flanked by a bishop saint on the left and the hermit saint Onuphrius on the right. The figures are arranged in a tight, triangular formation against a dark, indistinct background, which forces the viewer to focus on the interaction between the subjects.

Lotto, a Venetian painter who spent much of his career in the provinces, demonstrates a unique approach to religious iconography. The bishop saint is depicted with meticulous attention to his vestments and the pastoral staff, while the Christ Child reaches out with a naturalistic, childlike curiosity. To the right, St. Onuphrius is shown as an ascetic figure, his weathered skin and long beard contrasting with the soft, luminous flesh tones of the infant. The artist's signature and the date are inscribed at the top of the panel, confirming its origin during his time in Rome.

The painting is notable for its use of light, which models the forms and creates a sense of volume. The drapery, particularly the deep blue of the Virgin's mantle and the red of her undergarment, is rendered with precision. Lotto avoids the idealised, static quality found in some of his contemporaries, opting instead for a more humanised portrayal of sacred figures. This work provides a clear view into the stylistic transition occurring in early sixteenth-century Italian art, where the influence of Leonardo and Raphael began to merge with the specific traditions of the Venetian school. The panel remains a representative example of Lotto's ability to balance formal religious requirements with his own observational style.